Because pain and mental health are closely interconnected through shared brain and nervous system pathways, effective treatment addresses both physical and psychological factors. Evidence-based approaches such as Cognitive Behavioral Therapy (CBT), Acceptance and Commitment Therapy (ACT), mindfulness-based interventions, physical rehabilitation, and certain antidepressant medications can help reduce pain-related distress, improve daily functioning, and break the cycle between chronic pain, anxiety, and depression. While CBT helps individuals identify and modify unhelpful thoughts and behaviors related to pain, ACT emphasizes psychological flexibility by encouraging acceptance of pain while focusing on valued activities and meaningful life goals despite ongoing symptoms.